These are the guests of Season 4.
- Greg Hawkes
- Biz Markie
- Mark Mothersbaugh
- The Pains of Being Pure at Heart
- Mariachi El Bronx
- Paul Scheer
- Jack McBrayer
- Leslie Hall
- Erykah Badu
- Bootsy Collins
- Questlove
- Kemba Russell
- Papas Fritas
- My Chemical Romance
- Tori Spelling
- Matt Walsh (as Santa Claus)
- Tony Hawk
- James Husband
- Cults
- Josh Freese
- Kate Micucci
- Memoryhouse
- Slick Rick
- Justin Roiland (creator of Cartoon Network's "Rick and Morty")
- Yelle
- Bill Hader
- Metta World Peace
- Cut Copy
- Diamond World Peace
- Bibio
- Anne Heche
- Greg Hawkes
- Maddie Fretz (who has previously starred on Nick Jr.'s "Between Maids")
- Inara George
- Scottsdale Or Yacht
- Jason Bateman
- Peter, Bjorn and John
- The Stars
- Patton Oswalt
- CSS
- Edward Sharpe and the Magnetic Zeros
- George Clinton (who has previously guest starred on "Pancake Mountain")
- Busy Philipps
- Steve Caballero
- Tom Lennon
- Rocket from the Crypt
- Toro y Moi
- Belle and Sebastian
- Jeffrey Tambor
- Neon Indian
- Josh Holloway
- The High Llamas
- Dr. Dog
- Matthew Gray Gubler
- Todd Oldham
- Marissa Jaret Winokur
- The Roots