These were the guests of Season 3.
- "Weird Al" Yankovic
- Sarah Silverman
- Mark Mothersbaugh
- Paul Scheer
- Jack McBrayer
- Black Kids
- Mates of State
- Weezer (who have previously done the "Keep Fishin" music video with the Muppets)
- Mix Master Mike
- Black Moth Super Rainbow
- Tim Armstrong
- Anthony Bourdain
- Biz Markie
- Of Montreal
- Mos Def
- Devo (who have previously done the theme for "Rugrats")
- The Aquabats
- Robbert Bobbert of Apples in Stereo
- Solange Knowles (who has previously guest starred on "The Proud Family")
- Taking Back Sunday
- Rob Dyrdek
- Angela Kinsey
- The Faint
- Dr. Dog
- The Killers
- Chairlift
- Martin Starr
- John Francis Daley
- Samm Levine
- Super Furry Animals
- Marissa Jaret Winokur
- Band of Horses
- The Decemberists
- Fred Armisen
- Charlene Yi
- Blitzen Trapper
- Camera Obscura
- The Sounds
- DeVotchKa
- The Flaming Lips
- The Submarines